Molecular Cloning of the Rabbit Organic Cation Transporter, rbOCT2, and Functional Comparisons with rbOCT1
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چکیده
Cloning of the Rabbit Organic Cation Transporter, rbOCT2, and Functional Comparisons with rbOCT1. Am J. Physiol. Renal Physiol. Multiple organic cation (OC) transporters are present in rabbit kidney and may play different functional roles. We cloned rbOCT2 and compared its function with that of rbOCT1. In transiently transfected COS-7 cells, rbOCT1 and rbOCT2 mediated uptake of [ 3 H]tetraethylammonium (TEA) with K t s of 188 and 125 µM, respectively. n-Tetraalkylammonium compounds showed similar affinities for the two homologs, with IC 50 s for inhibition of OCT1-and OCT2-mediated [ 3
منابع مشابه
Molecular cloning of rabbit organic cation transporter rbOCT2 and functional comparisons with rbOCT1.
Multiple organic cation transporters (OCTs) are present in rabbit kidney and may play different functional roles. We cloned rabbit OCT2 (rbOCT2) and compared its function with that of rabbit OCT1 (rbOCT1). In transiently transfected COS-7 cells, rbOCT1 and rbOCT2 mediated uptake of [3H]tetraethylammonium (TEA) with K(t) values of 188 and 125 microM, respectively. n-Tetraalkylammonium compounds ...
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